tessa
CommunityIntegrate TCR data with RNA to map T cell states.
Authorpwwang
Version1.0.0
Installs0
System Documentation
What problem does it solve?
TESSA addresses the challenge of mapping the functional landscape of T cells by integrating TCR sequence profiling with transcriptomic profiles to reveal unified cellular states.
Core Features & Use Cases
- Integrates paired TCR sequences (TRA and TRB) with RNA expression to construct a joint representation of T cells.
- Uses BriseisEncoder-based embeddings and Bayesian inference to cluster cells by combined TCR and expression features across samples or within-sample groups.
- Supports multi-dataset integration, antigen-specific T cell discovery, and longitudinal or cross-sample analyses.
Quick Start
Provide a Seurat object with paired TCR and RNA data and run the TESSA process to obtain TESSA clusters.
Dependency Matrix
Required Modules
None requiredComponents
Standard package💻 Claude Code Installation
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Please help me install this Skill: Name: tessa Download link: https://github.com/pwwang/immunopipe/archive/main.zip#tessa Please download this .zip file, extract it, and install it in the .claude/skills/ directory.
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