solublempnn

What problem does it solve?

This Skill automates solubility-optimized protein sequence design for a given backbone, helping researchers improve expression yields and reduce aggregation in challenging targets.

Core Features & Use Cases

• SolubleMPNN integration: design sequences using soluble model weights to enhance solubility for Escherichia coli expression.
• Design modes: supports standard ProteinMPNN design and ligand-aware LigandMPNN workflows as referenced by the skill guidelines.
• Guided workflows: generate multiple sequences per backbone, evaluate solubility and folding propensity, and select candidates for experimental testing.

Quick Start

Design a sequence for backbone.pdb using the soluble model. For example, use the Modal wrapper to run the soluble design with backbone.pdb and model v_48_020.