proteinmpnn
OfficialDesign protein sequences via ProteinMPNN.
Education & Research#inverse-folding#multi-state-design#sequence-design#protein-design#backbone-design#ProteinMPNN
Authoradaptyvbio
Version1.0.0
Installs0
System Documentation
What problem does it solve?
This Skill enables automated design of protein sequences using ProteinMPNN inverse folding, turning structural backbones into viable sequences.
Core Features & Use Cases
- Inverse-folding sequence design: generate sequences that fit a given backbone.
- Redesign and constraint handling: modify existing sequences and apply fixed-position constraints.
- Multi-state and expression considerations: optimize sequences for stability and expression, including multi-state design.
Quick Start
Run a basic design for a given backbone with: python protein_mpnn_run.py --pdb_path backbone.pdb --out_folder output/ --num_seq_per_target 16 --sampling_temp "0.1"
Dependency Matrix
Required Modules
None requiredComponents
scriptsreferences
💻 Claude Code Installation
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Please help me install this Skill: Name: proteinmpnn Download link: https://github.com/adaptyvbio/protein-design-skills/archive/main.zip#proteinmpnn Please download this .zip file, extract it, and install it in the .claude/skills/ directory.
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