pgdh_rfdiffusion3
CommunityDesign PGDH binders with RFdiffusion3
Authoralex-hh
Version1.0.0
Installs0
System Documentation
What problem does it solve?
This Skill automates the generation of atomic-level protein binders targeting the 15-PGDH enzyme using the advanced RFdiffusion3 tool.
Core Features & Use Cases
- Atomic-level Design: Generates full sidechain placements for binders, not just backbones.
- Targeted Binding: Supports designing binders for specific sites like the active site or dimer interface of 15-PGDH.
- Use Case: Generate novel protein binders that can block the active site of 15-PGDH to inhibit its function, using a specified set of hotspot residues.
Quick Start
Use the pgdh_rfdiffusion3 skill to generate 4 PGDH active site binder designs using the rosettacommons/foundry Docker image on Lyceum.
Dependency Matrix
Required Modules
None requiredComponents
scriptsreferences
💻 Claude Code Installation
Recommended: Let Claude install automatically. Simply copy and paste the text below to Claude Code.
Please help me install this Skill: Name: pgdh_rfdiffusion3 Download link: https://github.com/alex-hh/in-silico-pgdh/archive/main.zip#pgdh-rfdiffusion3 Please download this .zip file, extract it, and install it in the .claude/skills/ directory.
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