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differential-tad-analysis

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Detect differential TADs to map chromatin changes

Data & Analytics#genomics#hic#chromatin#differential-tad#hicexplorer#tad-analysis
AuthorBIsnake2001
Version1.0.0
Installs0

System Documentation

What problem does it solve?

Identify differential TADs between two conditions by comparing normalized Hi-C matrices with HiCExplorer's hicDifferentialTAD to reveal significantly altered chromatin domains.

Core Features & Use Cases

  • Normalize Hi-C matrices from two conditions for fair comparison.
  • Compute differential TADs using HiCExplorer and output BED/GFF/TAD score reports.
  • Visualize differential interactions and map changes onto contact maps for interpretation.

Quick Start

Provide target and control sample names, genome assembly, and Hi-C data paths to begin the differential TAD workflow.

Dependency Matrix

Required Modules

None required

Components

Standard package

💻 Claude Code Installation

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Please help me install this Skill:
Name: differential-tad-analysis
Download link: https://github.com/BIsnake2001/ChromSkills/archive/main.zip#differential-tad-analysis

Please download this .zip file, extract it, and install it in the .claude/skills/ directory.
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