UMR-LMR-PMD-detection

What problem does it solve?

This pipeline identifies unmethylated regions (UMRs), low-methylated regions (LMRs), and partially methylated domains (PMDs) from whole-genome bisulfite sequencing data, enabling discovery of enhancer-like hypomethylated regions and large-scale methylome domains.

Core Features & Use Cases

• Genome-wide segmentation of CpG methylation to annotate UMRs, LMRs, PMDs.
• Outputs BED annotations for UMRs/LMRs/PMDs and supports integration with other epigenomic data (ATAC-seq, CHiP-seq).
• Use Case: For aging or cancer methylomes, identify PMDs and regulatory hypomethylation patterns to link to chromatin states.

Quick Start

Run the UMR-LMR-PMD-detection workflow on your WGBS methylation data to produce BED outputs for UMRs, LMRs, and PMDs.