tiledbvcf

What problem does it solve?

This Skill addresses the challenge of efficiently storing, querying, and analyzing large-scale genomic variant data, which is often cumbersome with traditional VCF/BCF formats.

Core Features & Use Cases

• Scalable Storage: Ingest and store VCF/BCF data using TileDB's sparse array technology for efficient access.
• Efficient Querying: Perform rapid queries across genomic regions and samples, ideal for population genomics.
• Incremental Updates: Add new samples to existing datasets without costly re-processing.
• Use Case: Researchers can quickly query allele frequencies for specific genes across thousands of samples or export subsets of variant data for downstream analysis.

Quick Start

Use the tiledbvcf skill to create a new dataset and ingest samples from 'sample1.vcf.gz' and 'sample2.vcf.gz'.