scientific-nci60-screening

Integrate NCI-60, CellMiner, and DepMap data to analyze cancer cell line drug responses.

3|1|Updated Feb 11, 2026
One-click install
npx skills add https://github.com/nahisaho/satori --skill scientific-nci60-screening
Or copy as Structured Prompt for Agent▼
Please help me install this Agent Skill.
Skill: scientific-nci60-screening
Source: https://github.com/nahisaho/satori/tree/main/src/.github/skills/scientific-nci60-screening
Command: npx skills add https://github.com/nahisaho/satori --skill scientific-nci60-screening

SYSTEM DOCUMENTATION & REQUIREMENTS

What problem does it solve?

Provides an integrated pipeline to analyze cancer cell line drug responses using NCI-60, CellMiner, and DepMap data, enabling robust cross-dataset insights.

Core Features & Use Cases

  • Integrates high-throughput screening data (GI50/LC50) and dependency scores to identify drug sensitivity patterns across cell lines.
  • Enables biomarker correlations between molecular features and drug responses, and cross-panel comparisons (NCI-60 vs DepMap).
  • Use Case: compare GI50 trends across cell lines and link them to molecular markers to prioritize compounds for further study.

Quick Start

Invoke the nci60_screening_pipeline with a drug name or NSC ID to produce integrated NCI-60/DepMap results.

Frequently Asked Questions about scientific-nci60-screening

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I analyze NCI-60 drug sensitivity data alongside DepMap dependency scores?▼

To analyze NCI-60 drug sensitivity with DepMap scores, this Skill integrates CellMiner GI50/LC50 data with dependency scores to identify drug response patterns across cancer cell lines. It cross-references datasets to pinpoint compound sensitivity trends for molecular marker prioritization.

What is the best way to correlate molecular biomarkers with GI50 drug response data?▼

Correlating biomarkers with GI50 drug response data requires integrating CellMiner molecular features with NCI-60 screening results. This Skill computes correlations between molecular markers and drug sensitivity values to prioritize compounds for further study.

Can I compare NCI-60 panel screening results directly with DepMap cell line data?▼

Yes, you can compare NCI-60 panel screening results directly with DepMap data. The Skill performs cross-panel comparisons between NCI-60 GI50/LC50 metrics and DepMap dependency scores to highlight overlapping or divergent cancer cell line responses.

Do I need internet access to fetch CellMiner and NCI-60 screening data for analysis?▼

Yes, internet access is required to fetch CellMiner and NCI-60 screening data for analysis. The Skill connects to public data sources to retrieve GI50, LC50, and DepMap dependency scores for Python-based analytics.

How do I retrieve integrated drug screening results using an NSC ID?▼

To retrieve integrated drug screening results using an NSC ID, invoke the pipeline with that specific drug identifier. The Skill fetches corresponding NCI-60 and DepMap data to produce a unified drug sensitivity and dependency report.