phenotype-lab-spec

Generate YAML-ready phenotype and lab-usage definitions from EHR data.

Updated Jan 18, 2026
One-click install
npx skills add https://github.com/tito-gh/healthcare --skill phenotype-lab-spec
Or copy as Structured Prompt for Agent▼
Please help me install this Agent Skill.
Skill: phenotype-lab-spec
Source: https://github.com/tito-gh/healthcare/tree/main/.claude/skills/phenotype-lab-spec
Command: npx skills add https://github.com/tito-gh/healthcare --skill phenotype-lab-spec

SYSTEM DOCUMENTATION & REQUIREMENTS

What problem does it solve?

This Skill enables researchers and clinicians to translate complex phenotype and laboratory value criteria into machine-executable definitions, ensuring reproducibility and scalable validation across large EHR datasets.

Core Features & Use Cases

  • Computer-executable phenotype definitions: Create structured, reusable definitions for Population, Exposure, Outcome, and Covariates that can be run against EHR data.
  • Lab value mapping and time-series handling: Define lab variable mappings, normal ranges, and longitudinal processing to support robust analyses.
  • Validation planning and templates: Provide built-in validation templates (PPV targets, sensitivity targets) and evaluation plans to ensure clinical relevance.

Quick Start

Create a phenotype definition for an NDMM exposure to daratumumab using IMWG criteria, and generate an accompanying validation plan.

Frequently Asked Questions about phenotype-lab-spec

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I create computer-executable phenotype definitions from EHR data for clinical research?▼

To create computer-executable phenotype definitions from EHR data, you input structured parameters like PHENOTYPE_NAME, DRUG, INDICATION, and REFERENCE_DEFINITION to generate YAML-ready, machine-executable outputs covering population, exposure, outcome, and covariate phenotypes.

What is the best way to map lab values and handle time-series data when defining EHR phenotypes?▼

Mapping lab values and handling time-series data for EHR phenotypes requires defining lab variable mappings, normal ranges, and longitudinal processing specifications, which are structured to support robust clinical research analyses and reproducible execution.

How do I generate a validation plan for exposure phenotypes using IMWG criteria?▼

Generating a validation plan for exposure phenotypes using IMWG criteria involves applying built-in validation templates that specify PPV targets, sensitivity targets, and evaluation plans to ensure clinical relevance across large EHR datasets.

Do I need structured inputs to build covariate and outcome phenotypes from EHR data?▼

Yes, building covariate and outcome phenotypes from EHR data requires structured inputs such as PHENOTYPE_NAME, DRUG, and INDICATION to automate the creation of reproducible, machine-executable definitions and lab-usage specifications.

What format are the automated phenotype definitions output in for EHR data processing?▼

Automated phenotype definitions for EHR data processing are output in a YAML-ready format, enabling researchers to directly execute structured population, exposure, outcome, and covariate definitions against large datasets.

Can I use this approach to define phenotypes for both drug exposure and disease indications?▼

Yes, you can define phenotypes for both drug exposure and disease indications by providing structured inputs like DRUG and INDICATION, translating complex clinical criteria into machine-executable definitions with scalable validation planning.