onek-genomes

Ingest 1000 Genomes VCFs and sample metadata into Hail MatrixTables.

Updated Feb 2, 2024
One-click install
npx skills add https://github.com/bigbio/hvantk --skill onek-genomes
Or copy as Structured Prompt for Agent▼
Please help me install this Agent Skill.
Skill: onek-genomes
Source: https://github.com/bigbio/hvantk/tree/main/hvantk/skills/onek_genomes
Command: npx skills add https://github.com/bigbio/hvantk --skill onek-genomes

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill requires hail, requests, and includes scripts (resource) components.

What problem does it solve?

This Skill solves the complexity of managing and integrating large-scale 1000 Genomes Project high-coverage variant data and sample metadata into Hail-based multiomics analysis pipelines.

Core Features & Use Cases

  • Variant Matrix Construction: Imports per-chromosome bgzipped VCFs into a unified Hail MatrixTable for scalable analysis.
  • Sample Metadata Integration: Automatically fetches and processes IGSR canonical sample panels to annotate variant cohorts.
  • Use Case: Researchers can use this to build a standardized 1000 Genomes reference cohort, enabling rapid population-level variant frequency analysis or ancestry inference.

Quick Start

Run the hvantk reprocess onek-genomes:variants command with your local VCF directory path to build the variant cohort MatrixTable.

Frequently Asked Questions about onek-genomes

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I ingest 1000 Genomes VCFs into Hail MatrixTables for variant analysis?▼

To ingest 1000 Genomes VCFs into Hail MatrixTables, run the provided reprocess command with your local VCF directory path to build a unified variant cohort for scalable analysis.

What is the best way to integrate IGSR sample metadata into a Hail genomics workflow?▼

The best way to integrate IGSR sample metadata into a Hail genomics workflow is using this Skill, which automatically fetches and processes canonical sample panels to annotate variant cohorts.

Do I need Hail installed to process 1000 Genomes high-coverage variant callsets?▼

Yes, you need Hail installed to process 1000 Genomes high-coverage variant callsets, as this Skill depends on the Hail framework to construct MatrixTables for large-scale genomic data pipelines.

Can I build a standardized reference cohort for ancestry inference using 1000 Genomes data?▼

Yes, you can build a standardized 1000 Genomes reference cohort for ancestry inference by using this Skill to ingest variant callsets and integrate sample metadata into Hail MatrixTables.

Does this Skill support large-scale population-level variant annotation tasks?▼

Yes, this Skill supports large-scale population-level variant annotation tasks by facilitating the integration of 1000 Genomes Project variant data and sample metadata into Hail workflows.