nested-TAD-detection
CommunityDetect hierarchical TADs from Hi-C with OnTAD.
AuthorBIsnake2001
Version1.0.0
Installs0
System Documentation
What problem does it solve?
This skill enables detection of nested TAD structures from Hi-C data using OnTAD, starting from multi-resolution cooler files (.mcool, .cool) and producing organized TAD calls for downstream analysis.
Core Features & Use Cases
- Extract a dense Hi-C matrix for a chosen chromosome and resolution from an mcool/cool/hic file.
- Run OnTAD to identify hierarchical TADs and sub-TADs, and generate BED-like and annotation outputs.
- Validate matrix quality and standardize OnTAD results for integration with downstream analyses (e.g., boundaries, regulatory features).
Quick Start
Provide the Hi-C mcool path, chromosome name, and resolution to begin nested TAD detection.
Dependency Matrix
Required Modules
None requiredComponents
Standard package💻 Claude Code Installation
Recommended: Let Claude install automatically. Simply copy and paste the text below to Claude Code.
Please help me install this Skill: Name: nested-TAD-detection Download link: https://github.com/BIsnake2001/ChromSkills/archive/main.zip#nested-tad-detection Please download this .zip file, extract it, and install it in the .claude/skills/ directory.
Agent Skills Search Helper
Install a tiny helper to your Agent, search and equip skill from 223,000+ vetted skills library on demand.