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Refine VHH nanobody binders with mBER.

Design & Creative#protein-design#binder-design#nanobody#mber#vhh#cdr-design#af-multimer
Authorjunior1p
Version1.0.0
Installs0

System Documentation

What problem does it solve?

mBER enables the design and refinement of VHH nanobody binders against protein targets using structure-conditioned generation and AlphaFold-Multimer guidance.

Core Features & Use Cases

  • Structure-conditioned VHH binder design leveraging AF-Multimer conditioning
  • CDR1/CDR2/CDR3 loop redesign on existing scaffolds with hotspot targeting
  • Multi-chain antigen handling with chain-offset support for complex targets

Quick Start

Provide a target protein and run the mBER design workflow to generate a VHH binder against it.

Dependency Matrix

Required Modules

None required

Components

Standard package

💻 Claude Code Installation

Recommended: Let Claude install automatically. Simply copy and paste the text below to Claude Code.

Please help me install this Skill:
Name: mber
Download link: https://github.com/junior1p/ProteinClaw/archive/main.zip#mber

Please download this .zip file, extract it, and install it in the .claude/skills/ directory.
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