ligandmpnn-reference

What problem does it solve?

This Skill provides quick access to essential information and parameters for LigandMPNN, a powerful tool for protein sequence design, particularly when dealing with ligands, metals, or membrane proteins.

Core Features & Use Cases

• Model Selection: Understand and choose between different MPNN model types (protein_mpnn, ligand_mpnn, etc.).
• Parameter Configuration: Quickly reference key command-line arguments for biasing amino acids, fixing residues, controlling temperature, and packing side chains.
• Use Case: When designing a protein to bind a specific metal ion, you can use this Skill to find the appropriate bias presets and parameters for ligand_mpnn to guide the sequence design.

Quick Start

Use the ligandmpnn-reference skill to find the correct bias_AA parameters for designing a protein that binds to a lanthanide.