lifesciences-crispr
CommunityValidate CRISPR synthetic lethality with ORCS data.
System Documentation
What problem does it solve?
Validates synthetic lethality claims from CRISPR knockout screens using BioGRID ORCS 5-phase workflow. This skill should be used when the user asks to "validate synthetic lethality", "query CRISPR essentiality data", "find gene dependencies", "compare cell line screens", or mentions BioGRID ORCS, gene knockout data, essentiality scores (CERES, MAGeCK, BAGEL), or asks to validate claims from published CRISPR papers.
Core Features & Use Cases
- 5-phase workflow for CRISPR essentiality validation using BioGRID ORCS.
- Resolve gene identifiers, fetch essential screens, annotate cells, and compare dependencies with CERES, MAGeCK, and BAGEL scores.
- Generate evidence-backed conclusions with provenance across diverse cell lines and genetic backgrounds.
Quick Start
Query CRISPR essentiality screens for a gene in ORCS and interpret significant synthetic-lethality scores across cell lines.
Dependency Matrix
Required Modules
None requiredComponents
💻 Claude Code Installation
Recommended: Let Claude install automatically. Simply copy and paste the text below to Claude Code.
Please help me install this Skill: Name: lifesciences-crispr Download link: https://github.com/donbr/lifesciences-deepagents/archive/main.zip#lifesciences-crispr Please download this .zip file, extract it, and install it in the .claude/skills/ directory.
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