liana-py-complete

What problem does it solve?

LIANA+ provides an all-in-one framework to infer, analyze, and visualize cell-cell communication from single-cell, spatially resolved, and multimodal omics data, consolidating multiple methods and resources into a unified workflow.

Core Features & Use Cases

• Unified CCC inference: combines LIANA+ methods (CellPhoneDB, NATMI, CellChat, etc.) across samples and modalities.
• Spatial and multi-modal support: handles RNA, spatial coordinates, and multimodal data (e.g. CITE-seq) with tensor and Misty-based analyses.
• Versatile outputs: supports rank aggregation, multi-view representations, diffusion-like analyses, and visualization plots.
• Use Case: researchers compare CCC across conditions, build ligand-receptor gene sets, and integrate with Tensor-cell2cell or MOFA for downstream analyses.

Quick Start

• Use the liana-py-complete skill to load LIANA+ resources and run a basic CCC analysis on your dataset.