Lesion-Symptom Mapping Guide

What problem does it solve?

This skill provides a structured, domain-expert guide for planning and executing brain-lesion–behavior analyses, including voxel-based lesion-symptom mapping (VLSM), disconnection analyses, and network-based lesion mapping.

Core Features & Use Cases

• Methodology framework: step-by-step guidance for VLSM, disconnection analyses with BCBToolkit, and network lesion mapping using normative connectomes.
• Research planning protocols: guidance on study design, sample size, covariates, and reporting standards derived from Sperber, DeMarco & Turkeltaub, and Kimberg et al.
• Tooling & references: recommended software (NiiStat, LESYMAP, FSL, ANTs) and links to reference documents for robust brain-behavior inference.
• Use Case: Design and interpret chronic-stroke lesion studies with voxel-, tract-, and network-level analyses in cognitive neuroscience.

Quick Start

Begin by preparing lesion masks, registering to MNI space with cost-function masking, and following the step-by-step VLSM workflow to interpret results across voxel, tract, and network levels.