iggm

What problem does it solve?

Antibody and nanobody CDR design is time-consuming and requires specialized models to produce antigen-conditioned, diverse, and structurally compatible loop sequences. IgGM streamlines CDR generation and redesign by taking X-masked FASTA inputs and a target antigen structure to produce candidate sequences and co-folded complexes ready for downstream validation.

Core Features & Use Cases

• VHH (nanobody) design: De novo CDR loop generation for single-chain VHH scaffolds using X-marked positions.
• Full antibody (H+L) CDR design: Joint heavy and light chain CDR generation conditioned on an antigen epitope.
• CDR redesign and epitope targeting: Redesign specific CDRs while preserving framework residues and target defined epitopes.
• Practical outputs: Produces designed FASTA sequences, co-folded complex PDBs, and confidence scores for ranking candidates.
• Integration: Works with downstream validation skills such as chai and protenix and quality filters like protein-qc.

Quick Start

Design 20 nanobody CDR variants against antigen.pdb chain A using an X-marked FASTA and request FASTA, PDB, and scores for each design.