homer-motif-analysis

What problem does it solve?

This Skill identifies regulatory DNA sequence patterns (motifs) enriched in genomic regions, helping to understand which transcription factors might be active.

Core Features & Use Cases

• De Novo Motif Discovery: Finds novel, over-represented sequence patterns in your peak sets.
• Known Motif Enrichment: Checks if your peaks match known transcription factor binding motifs from databases like JASPAR.
• Peak Annotation: Assigns genomic features (promoters, introns, etc.) and nearest genes to your peaks.
• Use Case: After performing ChIP-seq for a transcription factor, use this Skill to discover its binding motif and annotate the bound regions to nearby genes, validating your experiment and revealing regulatory targets.

Quick Start

Run de novo and known motif discovery on the provided ChIP-seq peak file using the hg38 genome.