gtopdb-database
CommunityQuery GtoPdb for drug-target interactions.
Authorjaechang-hits
Version1.0.0
Installs0
System Documentation
What problem does it solve?
This Skill provides programmatic access to the Guide to Pharmacology (GtoPdb) database, enabling users to retrieve detailed information about drug-target interactions, ligand pharmacology, and target classifications.
Core Features & Use Cases
- Target & Ligand Information: Search and retrieve comprehensive details for pharmacological targets and their associated ligands.
- Interaction Data: Query quantitative affinity data (pKi, pIC50, pEC50) for receptor-ligand pairs.
- Selectivity Profiling: Build selectivity profiles for ligands across various targets.
- Use Case: A medicinal chemist needs to understand the known antagonists for a specific GPCR. They can use this Skill to query GtoPdb for all antagonists of that receptor, along with their reported affinities, to inform lead optimization strategies.
Quick Start
Use the gtopdb-database skill to find the beta-2 adrenoceptor target and list its approved drug interactions.
Dependency Matrix
Required Modules
requestspandasmatplotlib
Components
scriptsreferences
💻 Claude Code Installation
Recommended: Let Claude install automatically. Simply copy and paste the text below to Claude Code.
Please help me install this Skill: Name: gtopdb-database Download link: https://github.com/jaechang-hits/SciAgent-Skills/archive/main.zip#gtopdb-database Please download this .zip file, extract it, and install it in the .claude/skills/ directory.
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