Skills
.Work. You
Rest

group-sequential-methods

Community

Plan interim analyses with robust group-sequential designs.

Data & Analytics#simulation#clinical-trials#group-sequential#interim-analysis#alpha-spending#futility#gsdesign2
Authorchoxos
Version1.0.0
Installs0

System Documentation

What problem does it solve?

Design and evaluation of group sequential trials with interim analyses, managing alpha spending and futility boundaries to preserve statistical properties and efficiency.

Core Features & Use Cases

  • Designs for group sequential trials with predefined analysis timing
  • Alpha-spending strategies (OBF, Pocock, HSD) and their practical trade-offs
  • Simulation-based validation using simtrial and gsDesign2 to compare stopping boundaries
  • Use cases include regulatory submissions, DSMB planning, and rapid decision-making in trials

Quick Start

Run a GS simulation with simtrial and gsDesign2 to illustrate how boundaries affect early stopping

Dependency Matrix

Required Modules

None required

Components

Standard package

💻 Claude Code Installation

Recommended: Let Claude install automatically. Simply copy and paste the text below to Claude Code.

Please help me install this Skill:
Name: group-sequential-methods
Download link: https://github.com/choxos/BiostatAgent/archive/main.zip#group-sequential-methods

Please download this .zip file, extract it, and install it in the .claude/skills/ directory.
View Source Repository

Agent Skills Search Helper

Install a tiny helper to your Agent, search and equip skill from 223,000+ vetted skills library on demand.