differential-methylation

What problem does it solve?

Analyze differential DNA methylation between experimental conditions using WGBS methylation tracks (BED/BedGraph) and produce DMR and DMC calls with ready-to-use inputs and visuals.

Core Features & Use Cases

• Standardizes heterogeneous BED inputs into per-sample four-column Metilene tables (chrom, start, end, methylation_fraction) and merges them for analysis.
• Runs Metilene to detect DMRs and DMCs with tunable parameters and produces filtered results.
• Generates quick visualizations such as Δmethylation vs –log10(q) and length histograms for interpretation.
• Use Case: researchers comparing case vs control methylation to identify differential methylation patterns across the genome.

Quick Start

Provide per-sample BED methylation files and execute the metilene-based workflow to obtain DMR and DMC results along with visuals.