cdr3aaphyschem
CommunityCompare CDR3 properties across TCR groups.
Data & Analytics#regression#tcr#cdr3#physicochemical#length-distribution#biophysics#repertoire-analysis
Authorpwwang
Version1.0.0
Installs0
System Documentation
What problem does it solve?
Analyzes physicochemical properties of CDR3 amino acid sequences to understand biochemical characteristics of T-cell receptor repertoires. Performs regression analysis between two cell groups at different CDR3 lengths for each physicochemical feature (hydrophobicity, volume, isoelectric point, etc.).
Core Features & Use Cases
- Regression analysis across CDR3 properties by length to compare groups (e.g., Treg vs Tconv).
- Property calculation for eight physicochemical features (length, gravy, bulkiness, polarity, aliphatic, charge, acidic, aromatic).
- Flexible configuration across single or multi-sample datasets and across TRA/TRB chains.
Quick Start
Run the CDR3AAPhyschem process on an ScRepCombiningExpression output to compare physicochemical properties across cell groups.
Dependency Matrix
Required Modules
None requiredComponents
Standard package💻 Claude Code Installation
Recommended: Let Claude install automatically. Simply copy and paste the text below to Claude Code.
Please help me install this Skill: Name: cdr3aaphyschem Download link: https://github.com/pwwang/immunopipe/archive/main.zip#cdr3aaphyschem Please download this .zip file, extract it, and install it in the .claude/skills/ directory.
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