bulkrna-splicing
OfficialAnalyze alternative splicing events.
AuthorTianGzlab
Version1.0.0
Installs0
System Documentation
What problem does it solve?
This Skill automates the complex and time-consuming process of quantifying alternative splicing events and identifying significant differential splicing between conditions from bulk RNA-seq data.
Core Features & Use Cases
- PSI Quantification: Calculates Percent Spliced In (PSI) values for various splicing event types (SE, A5SS, A3SS, MXE, RI).
- Differential Splicing Detection: Identifies statistically significant splicing events based on user-defined thresholds for Delta PSI and adjusted p-value.
- Visualization: Generates publication-ready plots including event type distribution, Delta PSI histogram, and a splicing volcano plot.
- Use Case: Researchers can quickly pinpoint genes with altered splicing patterns in disease versus control samples, leading to faster discovery of novel biomarkers or therapeutic targets.
Quick Start
Run the bulkrna-splicing skill with demo data to see an example analysis.
Dependency Matrix
Required Modules
numpypandasscipymatplotlib
Components
scripts
💻 Claude Code Installation
Recommended: Let Claude install automatically. Simply copy and paste the text below to Claude Code.
Please help me install this Skill: Name: bulkrna-splicing Download link: https://github.com/TianGzlab/OmicsClaw/archive/main.zip#bulkrna-splicing Please download this .zip file, extract it, and install it in the .claude/skills/ directory.
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