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binding-characterization

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Guided SPR and BLI binding characterization

Education & Research#troubleshooting#binding#characterization#SPR#BLI#kinetics#data-interpretation
Authoradaptyvbio
Version1.0.0
Installs0

System Documentation

What problem does it solve?

Guidance for SPR and BLI binding characterization experiments. Use when: (1) Planning binding kinetics experiments, (2) Troubleshooting poor/no binding signal, (3) Interpreting kinetic data artifacts, (4) Choosing between SPR vs BLI platforms.

Core Features & Use Cases

  • SPR vs BLI decision support: Helps decide the most appropriate platform for a given interaction.
  • Troubleshooting guidance: Provides strategies to diagnose and mitigate common binding issues.
  • Kinetic interpretation: Interprets artifacts and mass transport effects to improve data quality.
  • Use Case: For a high-affinity protein-ligand pair, follows a plan to evaluate Kon/Koff and assay conditions.

Quick Start

Use this skill to decide between SPR and BLI for a given binding interaction and outline the kinetic data interpretation steps.

Dependency Matrix

Required Modules

None required

Components

Standard package

💻 Claude Code Installation

Recommended: Let Claude install automatically. Simply copy and paste the text below to Claude Code.

Please help me install this Skill:
Name: binding-characterization
Download link: https://github.com/adaptyvbio/protein-design-skills/archive/main.zip#binding-characterization

Please download this .zip file, extract it, and install it in the .claude/skills/ directory.
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