archs4-database

What problem does it solve?

This Skill provides access to a vast repository of uniformly processed RNA-seq and ChIP-seq data, enabling users to query gene expression profiles, identify co-expressed genes, and search for relevant samples without needing to download or process raw data.

Core Features & Use Cases

• Gene Expression Query: Retrieve z-score normalized expression levels for genes across various human and mouse tissues.
• Co-expression Analysis: Find genes that are highly correlated in expression with a query gene, useful for inferring functional relationships.
• Sample Search: Discover RNA-seq samples based on metadata keywords like tissue type or disease condition.
• Bulk Data Access: Provides URLs for downloading large HDF5 expression matrices for in-depth, offline analysis.
• Use Case: You want to understand the tissue-specific expression pattern of a gene of interest (e.g., TP53) and identify genes that are co-expressed with it to infer potential pathway members.

Quick Start

Use the archs4-database skill to find the top 5 tissues where the gene 'TP53' is highly expressed.